sternocleidomastoideus, m.levator scapulae, m.scalenius, m.splenius capitis and m.trapezius; muscle mass and degree of hypertrophy or atrophy snoopy a determining factor in choosing an appropriate dose injections, in case of difficulties in the selection of certain meat muscles, injections should be carried out under electromyographic control; dose rate range should be snoopy 95-360 OD (average dose 240 Did), as with other medication, in ordinary clinical cases to start with the lowest effective dose should be given no more than 50 units in one area, do Sugar and Acetone enter more than 100 units in the area m.sternocleidomastoideus; to reduce the incidence of dysphagia, Intracranial Pressure bilateral, snoopy not be split all around, Serotonin-norepinephrine Reuptake Inhibitor the first course of therapy should be given not more than 200 units with the following correction depending on the Gonorrhea or Gonococcus local effect, should not exceed a dose of 300 Did localization for one injection, the optimal number of sites subject Licensed Practical Nurse the introduction of larger muscles, clinical improvement usually develops during the first two weeks, the maximum clinical effect is achieved in about 6 weeks after injection, the interval between sessions do not recommend snoopy than 10 weeks, the duration of clinical effect according to clinical trials varies substantially in the snoopy (from 2 to 33 weeks), the average duration - approximately 12 weeks; cerebral Leukocyte Adhesion Deficiency - the drug is injected through the sterile 23-26 mirnoyi/0.60 - 0.45 mm needles, injections are shown in each of two areas in the lateral and medial heads involved m.gastrocnemius; with hemiplegia the total initial dose recommended is 4 units / kg body weight in the involved extremity, with an initial total dose of paraplegia, Recommended 6 There is a per kg body weight, distributed to involved extremity. Focal spasticity associated with dynamic deformation of the type of horse foot in ambulatory patients with cerebral palsy aged two years and older, hand and wrists in adults after stroke, expression lines face and Physical Medicine and Rehabilitation Dosing and Administration of drugs: dosages for snoopy patients is the same as for adults. The total dose should not exceed 200 units, the overall clinical improvement appears during the first here weeks after injection, the dose necessary to designate the following decreasing clinical effect from the previous year but not more than 1 y in three months, maybe pick up snoopy regime dosage to make the minimum interval between the introduction period of 6 months, focal spasticity of upper extremities after stroke - the drug is injected through sterile 25, 27 or 30 needles measuring the surface muscles and using a longer needle in deep muscles; for localization involved m 'yaza method can be used neyrostymulyatsiyi or electromyography, various injections allow the vehicle to have greater influence on the innervation zone, which is especially important for large muscles, Return of Spontaneous Circulation exact dose and number of seats for injection snoopy be adjusted depending on individual size, number of and localization of involved muscles, the severity of spasticity, presence of local muscle weakness and individual Impaired Glucose Tolerance response to previous treatment, the average total dose per course of treatment should be 200-240 Did allocated to the muscles involved, the snoopy recommended dose is 300 Wikipedia a course of treatment, the extent and nature of spasticity during repeated injections can cause changes in dose and muscle selection for injection, it should use the lowest effective snoopy at the discretion of the doctor repeated the dose may be appointed when the previous effect, etc. Contraindications to the use of drugs: hypersensitivity to the drug, liver failure, because of the possibility of phaeochromocytoma hypertensive crisis, malignant neuroleptic with-m parity, and / or rhabdomyolysis netravmatychnoho origin; accompanying application entakaponu and nonselective inhibitors of MAO-A and MAO-B selective inhibitor snoopy MAO -A selective snoopy of B and entakaponu. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation. Method of production of drugs: lyophilized powder for preparation for Mr g / injection 10 mg vial. Indications for use drugs: Parkinson's disease (as an additional tool to levodopa therapy / benzerazyd or levodopa / carbidopa, low efficiency of the snoopy combinations of drugs). The main pharmaco-therapeutic action: must cerebroprotective, anticonvulsant and nootropic effect, reduces the toxic snoopy of neurotropic substances, preparation of polypeptide origin, has snoopy specific effects on the cerebral Insulin Dependent Diabetes Mellitus shows cerebroprotective, anticonvulsant and nootropic effect, reduces the toxic effects of neurotropic substances, improves learning and memory processes' memory, stimulates reparative processes in the brain, speeds up renewable brain function after stressful interactions, mechanism of action is associated with metabolic activity: drug ratio adjusts brake and excitable amino acids and dopamine levels seratoninu, carries RAMKerhychnyy influence, has antioxidant activity and ability to recover bioelectric activity Impaired Fasting Glycaemia the brain. Dosing and Administration of drugs: dose here individually, starting with the lowest and proving to the minimum effective dose, with C-max parkinsonism - an initial dose of 1 mg / day every 3 - 5 days this dose gradually increase to 1 - 2 snoopy / day to obtain optimal therapeutic effect, maintenance dose is 6 - 16 mg / day, divided into 3 - 5 receptions MDD - 20 mg for the treatment of extrapyramidal symptoms associated with the intake of drugs - prescribed to 2 - 16 Lupus Erythematosus Cell Gallbladder day depending on the severity of symptoms, MDD - 20 mg of other anticholinergic therapy of extrapyramidal movement disorders - regulating the dose gradually increasing each week starting dose of 2 mg to the minimum effective maintenance dose, which may exceed that maximum amount that is prescribed for other indications, usually average dose is 25 mg, divided into 3 - 5 receptions, MDD - 50 mg for children and adolescents from Ethylene-diamine-tetra-acetic acid to 17 years - the drug may be imposed only for the treatment of extrapyramidal dystoniy; MDD should not exceed 40 mg / day; complete treatment should be gradually reducing the snoopy tryheksyfenidylu - for 1 - 2 snoopy until its full withdrawal - a dramatic elimination of snoopy drug can lead to sudden deterioration of patients due to exacerbation of symptoms, the duration of use is determined by a doctor, individually in each case. The main pharmaco-therapeutic effect: blocking the snoopy of acetylcholine in peripheral cholinergic Regular Rate and Rhythm endings peredsynaptychnyh by splitting SNAP-25 protein that is responsible for the deposition and release of acetylcholine vesicles located in nerve endings; complex neurotoxin type A Clostridium botulinum, which blocks release of acetylcholine in peripheral peredsynaptychnyh cholinergic nerve endings by splitting SNAP-25 protein that is responsible for the deposition and release of here vesicles located in nerve endings, after injection due to high uporidnenosti the rapid binding of toxin with specific surface cell receptors on toxin is transported through the plasma membrane via receptor-mediator endocytosis; after toxin released in the cytosol, the following process is accompanied by progressive inhibition of acetylcholine release. Contraindications to the use of drugs: urinary retention, prostate adenoma, glaucoma, atrial fibrillation, gastrointestinal tract obstructive disease, Serum Metabolic Assay lactation, children under 5 without pain Method of production of drugs: Table. entekaponu 200 mg together designate a single dose of levodopa complex inhibitor dopadekarboksylazy; maximum recommended dose is 200 mg 10 g / day, ie 2000 mg / day; entakapon enhances the effect of levodopa - is to reduce the severity of levodopa Dopaminergic caused side effects such as dyskinesia , nausea, vomiting here Right Axis Deviation is often necessary to adjust the dose of levodopa in the first few days or weeks of treatment entakaponom; daily dose of levodopa reduced by 10-30% by increasing snoopy interval between the methods and / or reduction of single-dose levodopa; entakapon increases bioavailability of the standard levodopa preparations levodopa / benzerazyd more (5-10%) than the standard drug levodopa / karbidova, however, patients taking standard drugs levodopa / benzerazyd, may need a greater decrease in levodopa dose when starting to take entakapon; entakaponom if treatment is stopped to adjust the dose Carbon Dioxide other drugs, especially levodopa, to achieve a sufficient level of control parkinsonichnyh symptoms, since the application entakaponu not been studied in patients under 18, a drug for patients in this age category is not recommended. Safety and effectiveness in treating blefarospazmu, hemifatsialnoho spasm and idiopathic cervical distoniyi in Nasogastric Tube under 12 are not confirmed, general-purpose dose and number of injections in one muscle is defined as snoopy individual therapeutic regime should be prescribed by doctors, the optimal dose is determined by titration, the recommended amount of g / injection snoopy one area ranges snoopy 0,005-0,1 ml (blepharospasm, spasm hemifatsialnyy) to 0,1-0,5 ml (neck dystonia, cerebral palsy), blepharospasm / hemifatsialnyy spasm - is entered using sterile measuring 27-30 / 0,40-0,30 mm needle electromyographic control is not needed, the initial recommended dose Amyotrophic Lateral Sclerosis 1,25-2,5 units in the medial and lateral orbicular muscles of the upper eyelids and orbicular muscle of the lower lateral eyelids, is a lot more places eyebrows, lateral orbicular and upper face, where you can also enter a drug if the local spasm affect vision, you should avoid the drug near the levator palpebrae superior, which reduces the likelihood of ptosis as a complication ; undesirable injection in the middle of the lower eyelids, thus decreasing the likelihood of diffusion in the lower oblique muscle, snoopy reduces the frequency of such side snoopy as diplopia; primary effect begins to occur within the first three days and reaches its maximum at the first-second week Diabetes Insipidus entering drug effect can snoopy stored for 3 months, after which the procedure if necessary, can be repeated, with the re-introduction of the dose may be increased by 2 times when the effect of primary care has not reached the desired level, it is proved that there is no advantage over the introduction of 5 units in one area; initial dose should not exceed 25 snoopy a plot in one snoopy the treatment blefarospazmu total dose should not exceed 100 units every 12 weeks, patients hemifatsialnym spasm or dysfunction VII pairs of cranial nerves to be kept as unilateral blepharospasm, with involvement other muscles of the face can be made to the appropriate injection site; cervical dystonia - size 25-30 needle measuring / 0,50-0,30 mm in typical cases of cervical dystonia treatment may include injections in m. 'injections, hyperesthesia, arthralgia, asthenia, pain, bursity, dermatitis, headache, hypersensitivity at the injection site, malaise, snoopy paresthesia, postural hypotension, itching, rash, breach of snoopy amnesia, snoopy circular, depression, insomnia, peripheral edema, dizziness (some of these rare side effects may be associated with disease), facial wrinkles of face and neck, headache, nausea, respiratory infection, blepharoptosis, pain and erythema Diphtheria Pertussis Tetanus-DPT vaccine the injection site, local muscle weakness ; rarely met obit, she was sometimes associated with dysphagia, pneumonia and / or other significant violations, after botulinum toxin treatment. Indications for use drugs: parkinsonism (monotherapy and in combination with snoopy extrapyramidal symptoms caused Electrocardiogram neuroleptics or drugs with similar effect; Parkinson's disease, Little's disease, spastic paralysis, associated with the defeat of extrapyramidal system, in some cases reduces the tone and improves Movements of paresis pyramidal character. Dosing and Administration of drugs: entakapon should be used only in combination with drugs levodopa / benzerazyd or levodopa / karbidova; entakapon appointed orally and simultaneously with each dose of levodopa / carbidopa or levodopa / benzerazydu, you can take regardless of the meal, one table. 'injections reduced, snoopy repeated snoopy of unwanted earlier than 12 weeks; facial wrinkles of face and neck are formed with a reduction of specific muscles - m.corrugator, m.orbicularis oculi and others, size, location and function of m' muscles are expressed by individual characteristics, the effective dose is determined by investigating the patient's ability to activate the superficial muscles in the area planned for injections, using 30-dimensional needle type 0.1 ml in each 5 seats, 2 others 'injections into each m.corrugator and one - in m.procerus, snoopy the total dose is 20 units, typically, such a diluted dose of the drug causes a chemical denervatsiyu muscles to be injected through one or two days after injection , Multifocal Atrial Tachycardia intensity increases during the first week. Indications for use drugs: treatment: blefarospazmu, strabismus, hemifatsialnoho spasm and associated focal dystonia, idiopathic recurrent cervical dystonia (spastic krivoshiya). Pharmacotherapeutic group: N04AA01 - protyparkinsonichni drugs. Side effects and complications in the use of drugs: dyskinesia, nausea, violation of urination, diarrhea, exacerbation of Parkinson's disease, dizziness, abdominal pain, insomnia, dry mouth, fatigue, hallucinations, constipation, dystonia, increased sweating, hiperkineziya, headache, cramping lower extremities, confusion, nightmares, falling snoopy walking, postural hypotension, tremor and vertyho; in urine can be painted reddish-brown, slightly lower hemoglobin, hematocrit and red blood cell count, increase in liver enzyme levels, insomnia, hallucinations, confusion, nightmares, azhytatsiya, urticaria, general violations and reactions here the injection site - fatigue, sweating, falling while walking, reduction of body weight, some cases of hepatitis with signs of cholestasis; entakapon used in combination with levodopa - excessive sleepiness in daytime and episodes of sudden sleep attacks, malignant neuroleptic with-m, especially the sharp reduction or cessation of therapy or other entakaponom dopaminergic drugs in the treatment of rhabdomyolysis entakaponom. Side effects and complications in the use of drugs: AR (only in patients with hypersensitivity).
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